- Analytes
- HTRA1
HTRA1
Name: |
HtrA serine peptidase 1
|
Symbol: |
HTRA1
|
Version of Orphanet: |
2023-06-22 14:14:43
|
Synonyms: |
ARMD7
HtrA
IGFBP5-protease
|
XREF(s): | |
Created: |
13 May 2019 - 01:01
|
Changed: |
22 Jun 2023 - 16:14
|
- Cerebral autosomal recessive arteriopathy-subcortical infarcts-leukoencephalopathy
- HTRA1-related autosomal dominant cerebral small vessel disease
- Malignant peripheral nerve sheath tumor
- Malignant peripheral nerve sheath tumor with perineurial differentiation
- Malignant triton tumor
- NON RARE IN EUROPE: Age-related macular degeneration
-
Ataxia (348 genes) - ULB
Gene % of coding sequence sufficiently covered to detect heterozygous mutations Copy number variation Comments AAAS 100.00 0 No comment ABCB7 99.99 0 No comment ABCD1 97.56 0 No comment ABHD12 88.30 0 No comment ABHD5 99.85 0 No comment ACADVL 98.04 0 No comment ACO2 100.00 0 No comment COQ8A 99.92 0 No comment AFG3L2 94.80 0 No comment AHI1 100.00 0 No comment ALAS2 100.00 0 No comment ALDH18A1 100.00 0 No comment ALDH5A1 84.13 0 No comment ALG6 100.00 0 No comment ALS2 100.00 0 No comment AMACR 96.78 0 No comment AMPD2 99.90 0 No comment AMT 100.00 0 No comment ANO10 100.00 0 No comment AP1S2 100.00 0 No comment APTX 99.96 0 No comment ARL13B 99.98 0 No comment ARL6 100.00 0 No comment ARSA 100.00 0 No comment ARX 100.00 0 No comment ASPA 100.00 0 No comment ATCAY 100.00 0 No comment ATG5 100.00 0 No comment ATL1 99.89 0 No comment ATM 100.00 0 No comment ATP1A3 100.00 0 No comment ATP2B2 100.00 0 No comment ATP2B3 99.89 0 No comment ATP7B 100.00 0 No comment ATP8A2 99.91 0 No comment ATXN1 100.00 0 No comment ATXN10 98.19 0 No comment ATXN2 93.25 0 No comment ATXN3 99.47 0 No comment ATXN7 98.67 0 No comment B9D1 99.89 0 No comment BBS1 100.00 0 No comment BBS10 100.00 0 No comment BBS12 100.00 0 No comment BBS2 100.00 0 No comment BBS4 99.97 0 No comment BBS5 100.00 0 No comment BBS7 99.99 0 No comment BBS9 99.93 0 No comment BEAN1 100.00 0 No comment BIVM 100.00 0 No comment BSCL2 100.00 0 No comment BTD 100.00 0 No comment TWNK 100.00 0 No comment MTRFR 100.00 0 No comment C19ORF12 100.00 0 No comment CPLANE1 100.00 0 No comment CA8 100.00 0 No comment CACNA1A 99.53 0 No comment CACNA1G 99.97 0 No comment CACNB4 99.95 0 No comment CAMTA1 99.98 0 No comment CAPN1 99.97 0 No comment CASK 99.99 0 No comment CC2D2A 100.00 0 No comment CCDC88C 99.64 0 No comment CEP290 100.00 0 No comment CEP41 100.00 0 No comment CHMP1A 100.00 0 No comment CLCN2 100.00 0 No comment CLN5 98.80 0 No comment CLN6 90.40 0 No comment CLPP 97.95 0 No comment COA7 100.00 0 No comment COASY 100.00 0 No comment COG5 99.95 0 No comment COQ2 99.66 0 No comment COQ6 100.00 0 No comment COQ9 100.00 0 No comment COX20 95.39 0 No comment CP 100.00 0 No comment CRAT 99.29 0 No comment CSTB 98.75 0 No comment CWF19L1 100.00 0 No comment CYP27A1 99.38 0 No comment CYP2U1 93.20 0 No comment CYP7B1 95.41 0 No comment DARS1 100.00 0 No comment DARS2 100.00 0 No comment DDB2 100.00 0 No comment DDHD2 100.00 0 No comment DLAT 100.00 0 No comment DMXL2 100.00 0 No comment DNAJC19 99.65 0 No comment DNAJC3 99.99 0 No comment DNAJC5 100.00 0 No comment DNMT1 99.54 0 No comment EBF3 99.94 0 No comment EEF2 100.00 0 No comment EIF2B1 100.00 0 No comment EIF2B2 99.61 0 No comment EIF2B3 98.87 0 No comment EIF2B4 100.00 0 No comment EIF2B5 100.00 0 No comment ELOVL4 100.00 0 No comment ELOVL5 100.00 0 No comment EPM2A 97.21 0 No comment ERCC2 99.22 0 No comment ERCC3 100.00 0 No comment ERCC4 99.99 0 No comment ERCC5 100.00 0 No comment ETFA 100.00 0 No comment ETFB 100.00 0 No comment ETFDH 100.00 0 No comment EXOSC3 100.00 0 No comment FA2H 95.71 0 No comment FARS2 100.00 0 No comment FBXL4 100.00 0 No comment FDXR 100.00 0 No comment FGF14 100.00 0 No comment FLVCR1 100.00 0 No comment FMR1 99.99 0 No comment FOLR1 100.00 0 No comment FRMD7 99.98 0 No comment FXN 100.00 0 No comment GALC 98.98 0 No comment GBA1 100.00 0 No comment GBA2 100.00 0 No comment GBE1 100.00 0 No comment GCDH 100.00 0 No comment GCLC 99.98 0 No comment GCSH 73.97 0 No comment GFAP 100.00 0 No comment GJC2 96.72 0 No comment GLB1 100.00 0 No comment GLDC 97.39 0 No comment GLRX5 100.00 0 No comment GM2A 100.00 0 No comment GOSR2 100.00 0 No comment GPAA1 95.08 0 No comment GPR143 89.09 0 No comment ADGRG1 99.99 0 No comment GRID2 100.00 0 No comment GRM1 99.99 0 No comment GSS 100.00 0 No comment HARS2 100.00 0 No comment HEPACAM 99.85 0 No comment HERC1 100.00 0 No comment HEXA 100.00 0 No comment HEXB 99.19 0 No comment HIBCH 100.00 0 No comment HPRT1 92.71 0 No comment HTRA1 75.65 0 No comment IFRD1 98.86 0 No comment IGDCC3 95.07 0 No comment INPP5E 99.14 0 No comment IRF2BPL 97.56 0 No comment ITM2B 100.00 0 No comment ITPR1 99.99 0 No comment KCNA1 100.00 0 No comment KCNC3 76.20 0 No comment KCND3 100.00 0 No comment KCNJ10 100.00 0 No comment KCNJ6 100.00 0 No comment KCNMA1 99.93 0 No comment WASHC5 100.00 0 No comment RUBCN 96.60 0 No comment NEXMIF 100.00 0 No comment KIF1A 98.74 0 No comment KIF1C 100.00 0 No comment KIF5A 100.00 0 No comment KIF5C 100.00 0 No comment KIF7 99.64 0 No comment L2HGDH 99.75 0 No comment LAMA1 99.79 0 No comment LAMB1 100.00 0 No comment LARS2 100.00 0 No comment LMNB1 97.00 0 No comment LRPPRC 98.80 0 No comment LYST 100.00 0 No comment MFSD8 100.00 0 No comment MKKS 100.00 0 No comment MKS1 100.00 0 No comment MLC1 98.57 0 No comment MMACHC 100.00 0 No comment MME 100.00 0 No comment MRE11 99.05 0 No comment MSTO1 99.96 0 No comment MTFMT 97.83 0 No comment MTPAP 99.98 0 No comment MTRR 100.00 0 No comment MTTP 100.00 0 No comment MVK 100.00 0 No comment NANS 100.00 0 No comment NDUFAF6 95.61 0 No comment NDUFS1 100.00 0 No comment NDUFS2 100.00 0 No comment NDUFS4 99.96 0 No comment NDUFS7 93.34 0 No comment NDUFS8 100.00 0 No comment NDUFV1 99.62 0 No comment NEFL 99.62 0 No comment NEU1 100.00 0 No comment NHLRC1 96.01 0 No comment NKX6-2 94.10 0 No comment NOL3 100.00 0 No comment NOP56 99.99 0 No comment NOTCH3 93.46 0 No comment NPC1 97.50 0 No comment NPC2 100.00 0 No comment NPHP1 100.00 0 No comment NUBPL 99.92 0 No comment OCLN 100.00 0 No comment OFD1 97.13 0 No comment MED12 99.98 0 No comment OPA3 100.00 0 No comment OPHN1 99.94 0 No comment OTUD4 100.00 0 No comment PAX6 100.00 0 No comment PDGFRB 99.98 0 No comment PDHX 100.00 0 No comment PDSS1 85.11 0 No comment PDSS2 100.00 0 No comment PDYN 100.00 0 No comment PEX10 87.10 0 No comment PEX16 99.97 0 No comment PEX2 100.00 0 No comment PEX7 95.60 0 No comment PHYH 99.81 0 No comment PIK3R5 100.00 0 No comment PLA2G6 100.00 0 No comment PLEKHG4 100.00 0 No comment PLP1 100.00 0 No comment PMM2 100.00 0 No comment PMPCA 100.00 0 No comment PNKD 99.93 0 No comment PNKP 99.84 0 No comment PNPLA6 99.95 0 No comment POLG 100.00 0 No comment POLH 100.00 0 No comment POLR3A 100.00 0 No comment POLR3B 100.00 0 No comment PPP2R2B 100.00 0 No comment PRICKLE1 100.00 0 No comment PRKCG 100.00 0 No comment PRNP 99.92 0 No comment PRPS1 99.91 0 No comment PRRT2 100.00 0 No comment PTEN 99.45 0 No comment PUM1 100.00 0 No comment RAB18 99.99 0 No comment RAB3A 100.00 0 No comment RAB3GAP1 100.00 0 No comment RARS2 100.00 0 No comment RELN 100.00 0 No comment RNASEH2A 100.00 0 No comment RNASEH2C 100.00 0 No comment RNF170 100.00 0 No comment RNF216 100.00 0 No comment RPGRIP1L 96.40 0 No comment RRM2B 100.00 0 No comment SACS 99.95 0 No comment SAMD9L 100.00 0 No comment SAMHD1 100.00 0 No comment SAR1B 100.00 0 No comment SCN8A 100.00 0 No comment SEC16A 99.98 0 No comment SEPSECS 99.57 0 No comment SERAC1 100.00 0 No comment SETX 100.00 0 No comment SIL1 99.95 0 No comment SKOR1 98.57 0 No comment SLC16A2 99.97 0 No comment SLC17A5 100.00 0 No comment SLC19A3 99.90 0 No comment SLC1A3 100.00 0 No comment SLC20A2 100.00 0 No comment SLC25A15 100.00 0 No comment SLC25A46 100.00 0 No comment SLC2A1 100.00 0 No comment SLC39A8 98.92 0 No comment SLC52A2 100.00 0 No comment SLC52A3 99.86 0 No comment SLC9A1 100.00 0 No comment SLC9A6 99.66 0 No comment SMPD1 100.00 0 No comment SNX14 99.98 0 No comment SPAST 99.83 0 No comment SPG11 100.00 0 No comment SPG7 95.78 0 No comment SPR 99.98 0 No comment SPTBN2 99.93 0 No comment SRD5A3 98.61 0 No comment STUB1 99.69 0 No comment SYNE1 100.00 0 No comment SYT14 92.28 0 No comment TANGO2 99.94 0 No comment TBC1D20 95.06 0 No comment TBCC 100.00 0 No comment TBP 100.00 0 No comment TCTN1 100.00 0 No comment TCTN2 100.00 0 No comment TCTN3 100.00 0 No comment TDP1 100.00 0 No comment TDP2 100.00 0 No comment TGM6 100.00 0 No comment TK2 100.00 0 No comment TMEM138 100.00 0 No comment TMEM216 99.87 0 No comment TMEM231 100.00 0 No comment TMEM237 99.85 0 No comment TMEM240 96.75 0 No comment TMEM67 99.95 0 No comment ACD 99.99 0 No comment TRIM32 100.00 0 No comment TRPC3 99.48 0 No comment TSEN2 100.00 0 No comment TSEN34 100.00 0 No comment TSEN54 91.60 0 No comment TSFM 100.00 0 No comment TTBK2 100.00 0 No comment TTC19 100.00 0 No comment TTC8 99.73 0 No comment TTPA 96.80 0 No comment TUBB4A 100.00 0 No comment TUBG1 100.00 0 No comment TYMP 100.00 0 No comment UBA5 100.00 0 No comment VAMP1 100.00 0 No comment VLDLR 96.00 0 No comment VPS13A 100.00 0 No comment VPS13B 100.00 0 No comment VPS13D 100.00 0 No comment VRK1 100.00 0 No comment VWA3B 100.00 0 No comment WDPCP 99.11 0 No comment WDR73 100.00 0 No comment WDR81 99.63 0 No comment WFS1 100.00 0 No comment WWOX 100.00 0 No comment XPA 98.10 0 No comment XPC 100.00 0 No comment XPR1 99.91 0 No comment XRCC1 99.95 0 No comment ZC4H2 100.00 0 No comment ZFYVE26 100.00 0 No comment ZNF423 100.00 0 No comment ZNF592 100.00 0 No comment -
Dementia, young onset (gene panel)
Gene % of coding sequence sufficiently covered to detect heterozygous mutations Copy number variation Comments APOE 100.00 1 APP 100.00 1 CHCHD10 100.00 1 CHMP2B 100.00 1 CSF1R 100.00 1 FUS 100.00 1 GRN 100.00 1 HTRA1 95.00 1 ITM2B 100.00 1 MAPT 100.00 1 NOTCH3 98.00 1 OPTN 100.00 1 PRNP 100.00 1 PSEN1 100.00 1 PSEN2 100.00 1 TARDBP 100.00 1 TBK1 100.00 1 TREM2 100.00 1 TYROBP 100.00 1 UBQLN2 100.00 1 VCP 100.00 1 -
Leukodystrophy - UGent
Gene % of coding sequence sufficiently covered to detect heterozygous mutations Copy number variation Comments AARS2 99.98 1 ABAT 99.98 1 ABCD1 99.98 1 ACBD5 99.97 1 ACER3 99.76 1 ACOX1 99.98 1 ACP5 100.00 1 ACTL6B 99.90 1 ADAR 99.84 1 ADGRG1 99.90 1 ADSL 99.93 1 AGA 99.92 1 AIFM1 99.92 1 AIMP1 99.97 1 AIMP2 99.99 1 ALDH3A2 99.95 1 ALDH5A1 96.19 1 APP 99.92 1 ARSA 99.99 1 ASAH1 99.90 1 ASPA 99.98 1 ATAD3A 99.62 1 ATP7A 99.87 1 ATP7B 100.00 1 AUH 99.95 1 B3GALNT2 92.79 1 BCAP31 99.95 1 BCS1L 99.99 1 BOLA3 99.22 1 BTD 100.00 1 CBS 17.79 1 CIC 98.32 1 CLCN2 100.00 1 CLN3 99.92 1 CLN5 100.00 1 CLN6 100.00 1 CLN8 100.00 1 CNP 99.98 1 CNTNAP1 99.98 1 COA8 99.94 1 COL4A1 99.99 1 COL4A2 99.98 1 COX10 99.99 1 COX15 100.00 1 CYP21A2 99.91 1 CSF1R 99.92 1 CTC1 100.00 1 CTSA 99.98 1 CTSD 100.00 1 CTSF 99.96 1 CYP27A1 100.00 1 DAG1 100.00 1 DARS1 98.85 1 DARS2 98.31 1 DCAF17 99.84 1 DDHD2 99.97 1 DEGS1 99.99 1 DGUOK 99.93 1 DLAT 99.65 1 DLD 99.89 1 DMXL2 99.86 1 DNAJC5 99.99 1 EARS2 99.96 1 ECHS1 100.00 1 EIF2AK1 99.90 1 EIF2AK2 99.70 1 EIF2B1 99.98 1 EIF2B2 99.90 1 EIF2B3 97.26 1 EIF2B4 99.96 1 EIF2B5 99.98 1 EPRS1 99.53 1 ERCC2 99.98 1 ERCC3 99.90 1 ERCC6 99.60 1 ERCC8 99.79 1 FA2H 99.98 1 HYCC1 99.81 1 FAR1 99.82 1 FARS2 100.00 1 FASTKD2 99.93 1 FBXL4 100.00 1 FDX2 99.99 1 CFH 99.97 1 FIG4 99.83 1 FKTN 99.94 1 FLVCR2 100.00 1 FOLR1 100.00 1 FUCA1 98.72 1 GALC 99.92 1 GALT 100.00 1 GAN 99.98 1 GBE1 99.73 1 GFAP 99.99 1 GFM1 99.95 1 GFM2 99.87 1 GJA1 100.00 1 GJB1 100.00 1 GJC2 100.00 1 GLA 99.90 1 GLB1 100.00 1 GM2A 100.00 1 GNAS 100.00 1 GPHN 99.94 1 GRN 100.00 1 GTF2H5 100.00 1 HEPACAM 100.00 1 HEXA 99.99 1 HEXB 99.91 1 HIKESHI 99.78 1 HLCS 99.97 1 HMGCL 99.31 1 HSD17B4 99.71 1 HSPD1 83.42 1 HTRA1 100.00 1 IBA57 100.00 1 IFIH1 99.84 1 IKBKG 57.34 1 ISCA2 100.00 1 IVD 100.00 1 JAM3 100.00 1 KARS1 99.98 1 L2HGDH 99.92 1 LAMA2 99.95 1 LARGE1 100.00 1 LARS2 99.96 1 LIPT1 99.89 1 LIPT2 99.99 1 LMNB1 99.73 1 LYRM7 99.98 1 MAN2B1 99.99 1 MANBA 99.81 1 MARS2 100.00 1 MCOLN1 100.00 1 MFSD8 99.70 1 MLC1 99.99 1 MMUT 99.68 1 MOCS1 99.95 1 MOCS2 99.96 1 MPLKIP 99.99 1 MPV17 99.98 1 MRPS34 100.00 1 MTFMT 99.98 1 MTHFR 99.97 1 MTO1 90.25 1 NAXD 99.99 1 NAXE 99.99 1 NDUFA2 99.95 1 NDUFA9 100.00 1 NDUFAF1 100.00 1 NDUFAF3 100.00 1 NDUFAF4 99.95 1 NDUFAF6 99.86 1 NDUFS1 99.79 1 NDUFS2 99.66 1 NDUFS4 99.99 1 NDUFS7 99.99 1 NDUFS8 100.00 1 NDUFV1 99.99 1 NEU1 99.98 1 NKX6-2 100.00 1 NOTCH3 99.99 1 NPC1 99.99 1 NPC2 100.00 1 NTNG2 99.98 1 NUBPL 99.62 1 OCLN 82.91 1 OCRL 99.89 1 PAH 99.96 1 PARS2 99.99 1 PCCA 99.90 1 PCCB 99.97 1 PDGFB 99.99 1 PDGFRB 99.99 1 PDHA1 99.04 1 PDHB 99.94 1 PDHX 99.64 1 PDP1 100.00 1 PEX1 98.80 1 PEX10 100.00 1 PEX11B 99.62 1 PEX12 100.00 1 PEX13 99.36 1 PEX14 100.00 1 PEX16 99.94 1 PEX19 99.25 1 PEX2 100.00 1 PEX26 100.00 1 PEX3 99.85 1 PEX5 99.89 1 PEX6 99.99 1 PEX7 99.72 1 PLEKHG2 99.99 1 PLP1 99.98 1 PLPBP 99.99 1 PMPCB 99.94 1 PNPT1 99.56 1 POLG 100.00 1 POLR1C 100.00 1 POLR3A 99.97 1 POLR3B 99.94 1 POLR3K 100.00 1 POMGNT1 99.69 1 POMT1 99.96 1 POMT2 99.98 1 PPT1 97.48 1 PRF1 100.00 1 PSAP 99.94 1 PSAT1 99.98 1 PSPH 99.09 1 PYCR2 99.95 1 QDPR 99.92 1 RARS1 99.76 1 RNASEH2A 99.95 1 RNASEH2B 99.94 1 RNASEH2C 99.99 1 RNASET2 99.99 1 SAMHD1 99.98 1 SCP2 94.94 1 SDHA 99.98 1 SDHAF1 99.99 1 SDHAF2 99.96 1 SDHB 97.32 1 SDHD 82.93 1 SEPSECS 99.78 1 SGO1 99.90 1 SHANK3 98.45 1 SLC13A3 99.98 1 SLC16A2 99.97 1 SLC17A5 99.71 1 SLC20A2 99.95 1 SLC25A12 99.72 1 SLC44A1 99.90 1 SLC7A2 99.97 1 SNAP29 99.85 1 SNORD118 100.00 1 SOX10 100.00 1 SPG11 99.89 1 STN1 99.88 1 STX11 100.00 1 STXBP2 100.00 1 SUCLA2 99.96 1 SUMF1 99.95 1 SUOX 100.00 1 SURF1 100.00 1 TACO1 100.00 1 TMEM106B 99.92 1 TMEM63A 99.91 1 ACD 99.99 1 TREM2 100.00 1 TREX1 100.00 1 TSEN54 100.00 1 TTR 100.00 1 TUBB4A 100.00 1 TWNK 100.00 1 TYMP 99.87 1 TYROBP 99.95 1 UBTF 99.99 1 UFM1 99.25 1 UNC13D 100.00 1 VPS11 99.99 1 WARS2 97.72 1 WT1 99.99 1 XPR1 99.13 1 ZFYVE26 100.00 1 -
Neuropathy (148 genes) - IPG
Gene % of coding sequence sufficiently covered to detect heterozygous mutations Copy number variation Comments AARS1 100.00 1 NM_001605.3 ABHD12 100.00 1 NM_001042472.3 AIFM1 100.00 1 NM_004208.4 APTX 100.00 1 NM_001195248.2 ARHGEF10 100.00 1 NM_014629.4 ATL1 100.00 1 NM_015915.5 ATP1A1 100.00 1 NM_000701.8 ATP7A 100.00 1 NM_000052.7 BICD2 100.00 1 NM_001003800.2 BSCL2 100.00 1 NM_001122955.3 MTRFR 100.00 1 NM_152269.5 COX6A1 100.00 1 NM_004373.4 CTDP1 100.00 1 NM_004715.5 DCTN1 100.00 1 NM_004082.4 DHTKD1 100.00 1 NM_018706.7 DNAJB2 100.00 1 NM_006736.6 DNM2 100.00 1 NM_001005361.3 DNMT1 99.93 1 NM_001130823.3 DST 100.00 1 NM_001144770.2 DYNC1H1 100.00 1 NM_001376.5 EGR2 100.00 1 NM_000399.5 ELP1 100.00 1 NM_003640.5 FBLN5 100.00 1 NM_006329.3 FBXO38 100.00 1 NM_205836.3 FGD4 100.00 1 NM_001304480.1 FIG4 100.00 1 NM_014845.6 GAN 100.00 1 NM_022041.3 GARS1 100.00 1 NM_002047.4 GDAP1 100.00 1 NM_018972.4 GJB1 100.00 1 NM_000166.6 GJB3 100.00 1 NM_024009.3 GNB4 100.00 1 NM_021629.4 HARS1 100.00 1 NM_002109.6 HINT1 100.00 1 NM_005340.7 HK1 100.00 1 NM_001358263.1 HOXD10 100.00 1 NM_002148.4 HSPB1 100.00 1 NM_001540.5 HSPB3 100.00 1 NM_006308.3 HSPB8 100.00 1 NM_014365.3 IFRD1 100.00 1 NM_001007245.2 IGHMBP2 100.00 1 NM_002180.3 INF2 99.00 1 NM_022489.4 KARS1 100.00 1 NM_001130089.1 KIF1A 100.00 1 NM_001244008.1 KIF1B 100.00 1 NM_015074.3 KIF5A 100.00 1 NM_004984.4 LITAF 100.00 1 NM_001136472.1 LMNA 100.00 1 NM_170707.4 LRSAM1 100.00 1 NM_001005373.3 MARS1 100.00 1 NM_004990.4 MED25 100.00 1 NM_030973.3 MFN2 100.00 1 NM_014874.4 MME 100.00 1 NM_007289.4 MORC2 100.00 1 NM_001303256.3 MPZ 100.00 1 NM_000530.8 MTMR2 100.00 1 NM_016156.6 MYH14 100.00 1 NM_001145809.2 NAGLU 100.00 1 NM_000263.4 NDRG1 100.00 1 NM_006096.4 NEFH 100.00 1 NM_021076.4 NEFL 100.00 1 NM_006158.5 NGF 100.00 1 NM_002506.3 NTRK1 100.00 1 NM_002529.3 PDK3 100.00 1 NM_001142386.3 PEX1 100.00 1 NM_000466.3 PEX7 100.00 1 NM_000288.4 PHYH 100.00 1 NM_006214.4 PLEKHG5 100.00 1 NM_001265592.1 PMP22 100.00 1 NM_000304.4 POLG 100.00 1 NM_001126131.2 PRDM12 98.36 1 NM_021619.3 PRPS1 100.00 1 NM_002764.4 PRX 100.00 1 NM_181882.3 RAB7A 100.00 1 NM_004637.6 REEP1 100.00 1 NM_001371279.1 RETREG1 100.00 1 NM_001034850.2 SBF1 100.00 1 NM_002972.4 SBF2 100.00 1 NM_030962.3 SCN11A 100.00 1 NM_001349253.2 SCN9A 100.00 1 NM_001365536.1 SCO2 100.00 1 NM_005138.3 SETX 100.00 1 NM_015046.7 SH3TC2 100.00 1 NM_024577.4 SLC12A6 100.00 1 NM_001365088.1 SLC5A7 100.00 1 NM_021815.5 SOX10 100.00 1 NM_006941.4 SPG11 100.00 1 NM_025137.4 SPTLC1 100.00 1 NM_006415.4 SPTLC2 100.00 1 NM_004863.3 TDP1 100.00 1 NM_018319.4 TECPR2 100.00 1 NM_014844.5 TFG 100.00 1 NM_006070.6 TRIM2 100.00 1 NM_015271.5 TRPV4 100.00 1 NM_021625.5 TTR 100.00 1 NM_000371.4 TUBB3 100.00 1 NM_006086.4 TYMP 100.00 1 NM_001257989.1 VCP 100.00 1 NM_007126.5 WNK1 100.00 1 NM_018979.4 YARS1 100.00 1 NM_003680.3 AAAS 100.00 1 NM_015665.6 ALS2 100.00 1 NM_020919.4 ANG 100.00 1 NM_001145.4 ANXA11 100.00 1 NM_145868.2 ATL3 100.00 1 NM_015459.5 CNTNAP1 100.00 1 NM_003632.3 COA8 100.00 1 NM_001370595.1 COL4A1 100.00 1 NM_001845.6 DCAF8 100.00 1 NM_015726.4 DCX 100.00 1 NM_001195553.2 ERBB4 100.00 1 NM_005235.3 FUS 100.00 1 NM_004960.4 GBF1 100.00 1 NM_004193.3 GCH1 100.00 1 NM_000161.3 GLA 100.00 1 NM_000169.3 HTRA1 100.00 1 NM_002775.5 KLC2 100.00 1 NM_001134775.1 MATR3 100.00 1 NM_018834.6 MCM3AP 100.00 1 NM_003906.5 MPV17 100.00 1 NM_002437.5 NEK1 100.00 1 NM_001199397.3 NFASC 100.00 1 NM_001005388.2 OPTN 100.00 1 NM_001008212.2 PDXK 100.00 1 NM_003681.5 PFN1 100.00 1 NM_005022.4 PMP2 100.00 1 NM_002677.5 PNKP 100.00 1 NM_007254.4 PRPH 100.00 1 NM_006262.4 PTRH2 100.00 1 NM_016077.5 SCN10A 100.00 1 NM_006514.3 SEPTIN9 100.00 1 NM_001113491.2 SGPL1 100.00 1 NM_003901.4 SIGMAR1 100.00 1 NM_005866.4 SLC25A46 100.00 1 NM_138773.4 SMN1 6.96 1 NM_000344.3 SOD1 100.00 1 NM_000454.5 SORD 94.98 1 NM_003104.6 SQSTM1 100.00 1 NM_003900.5 SURF1 100.00 1 NM_003172.4 SYT2 100.00 1 NM_177402.5 TARDBP 100.00 1 NM_007375.4 TIA1 100.00 1 NM_022173.4 TRPA1 100.00 1 NM_007332.3 TUBA1A 100.00 1 NM_006009.4 TUBA4A 100.00 1 NM_006000.3 UBQLN2 100.00 1 NM_013444.3 VAPB 100.00 1 NM_004738.5 WARS1 100.00 1 NM_004184.4 -
Retinal dystrophy - UGent
Gene % of coding sequence sufficiently covered to detect heterozygous mutations Copy number variation Comments ABCA4 99.30 1 ABCC6 98.57 1 ABHD12 99.98 1 ACBD5 99.97 1 ACO2 99.99 1 ADAM9 99.89 1 ADAMTS18 99.99 1 ADGRA3 99.90 1 ADGRV1 99.80 1 ADIPOR1 99.83 1 AFG3L2 99.97 1 AGBL5 99.98 1 AHI1 99.86 1 AHR 99.79 1 AIPL1 100.00 1 ALMS1 99.90 1 ARHGEF18 99.97 1 ARL2BP 99.89 1 ARL3 99.98 1 ARL6 99.90 1 ARMS2 100.00 1 ARSG 100.00 1 ASRGL1 99.84 1 ATF6 98.19 1 ATXN7 99.98 1 BBIP1 99.99 1 BBS1 100.00 1 BBS10 99.98 1 BBS12 100.00 1 BBS2 99.90 1 BBS4 99.88 1 BBS5 99.00 1 BBS7 99.42 1 BBS9 99.75 1 BEST1 99.86 1 MFRP 100.00 1 C2 99.99 1 C3 100.00 1 CA4 100.00 1 CABP4 100.00 1 CACNA1F 99.94 1 CACNA2D4 99.99 1 CAPN5 99.88 1 CC2D2A 99.95 1 CCT2 98.46 1 CDH23 99.95 1 CDH3 99.98 1 CDHR1 99.72 1 CEP164 99.99 1 CEP19 99.99 1 CEP250 99.93 1 CEP290 98.10 1 CEP78 99.95 1 CERKL 99.91 1 CFAP410 100.00 1 CFAP418 100.00 1 CFB 99.97 1 CFH 99.12 1 CHM 96.46 1 CIB2 100.00 1 CLCC1 93.17 1 CLN3 99.92 1 CLRN1 99.99 1 CLUAP1 99.95 1 CNGA1 99.60 1 CNGA3 99.95 1 CNGB1 97.53 1 CNGB3 99.96 1 CNNM4 99.93 1 COL11A1 90.72 1 COL2A1 99.87 1 COL9A1 99.91 1 CRB1 99.73 1 CRX 99.96 1 CSPP1 98.31 1 CTNNA1 99.98 1 CWC27 99.67 1 CYP4V2 99.98 1 DHDDS 98.65 1 DHX38 99.97 1 DMD 99.76 1 DRAM2 96.06 1 DTHD1 99.92 1 DYNC2H1 99.66 1 EFEMP1 99.68 1 ELOVL1 100.00 1 ELOVL4 99.91 1 EMC1 99.85 1 ERCC6 99.60 1 ESPN 100.00 1 EXOSC2 100.00 1 EYS 99.86 1 FAM161A 99.77 1 FBLN5 100.00 1 FBN2 99.90 1 FLVCR1 99.91 1 FSCN2 100.00 1 FZD4 100.00 1 GDF6 100.00 1 GNAT1 100.00 1 GNAT2 99.87 1 GNB3 100.00 1 GNPTG 100.00 1 GPR179 99.99 1 GRID2 99.97 1 GRK1 99.99 1 GRM6 100.00 1 GUCA1A 100.00 1 GUCA1B 99.99 1 GUCY2D 100.00 1 HARS1 99.96 1 HGSNAT 99.93 1 HK1 99.97 1 HMCN1 99.44 1 HMX1 100.00 1 HTRA1 100.00 1 IDH3A 99.98 1 IDH3B 100.00 1 IFT140 100.00 1 IFT172 99.98 1 IFT27 100.00 1 IFT43 99.97 1 IFT81 94.64 1 IFT88 98.26 1 IMPDH1 92.77 1 IMPG1 99.93 1 IMPG2 99.97 1 INPP5E 99.85 1 INVS 99.94 1 IQCB1 99.72 1 ITM2B 99.85 1 JAG1 100.00 1 KCNJ13 99.99 1 KCNV2 99.97 1 KIAA1549 99.98 1 KIF11 99.84 1 KIF3B 99.99 1 KIZ 99.98 1 KLHL7 99.95 1 LAMA1 99.98 1 LAMB2 99.99 1 LCA5 99.89 1 LRAT 100.00 1 LRIT3 100.00 1 LRP5 99.95 1 LZTFL1 100.00 1 MAK 99.47 1 MAPKAPK3 99.97 1 MERTK 98.90 1 MFN2 99.98 1 MFSD8 99.70 1 MIR204 100.00 1 MKKS 100.00 1 MKS1 99.92 1 MTRFR 99.87 1 MTTP 99.92 1 MVK 99.97 1 MYO7A 99.96 1 NBAS 99.86 1 NDP 99.98 1 NEK2 95.09 1 NEUROD1 100.00 1 NMNAT1 99.93 1 NPHP1 99.05 1 NPHP3 99.89 1 NPHP4 99.98 1 NR2E3 100.00 1 NR2F1 99.99 1 NRL 100.00 1 NYX 100.00 1 OAT 90.17 1 OFD1 99.68 1 MED12 99.95 1 OPA3 100.00 1 OPN1LW 71.75 1 OPN1MW 30.23 1 OPN1SW 99.97 1 OTX2 100.00 1 PANK2 99.99 1 PAX2 99.99 1 PCARE 100.00 1 PCDH15 99.71 1 PCYT1A 100.00 1 PDE6A 99.98 1 PDE6B 100.00 1 PDE6C 99.91 1 PDE6G 100.00 1 PDE6H 99.97 1 PDZD7 98.09 1 PEX1 98.80 1 PEX2 100.00 1 PEX6 99.99 1 PEX7 99.72 1 PGK1 99.93 1 PHYH 100.00 1 PITPNM3 99.98 1 PLA2G5 99.91 1 PLK4 99.89 1 PNPLA6 99.99 1 POC1B 100.00 1 POC5 99.85 1 POMGNT1 99.69 1 PRCD 100.00 1 PRDM13 99.99 1 PROM1 99.97 1 PRPF3 99.73 1 PRPF31 99.99 1 PRPF4 99.96 1 PRPF6 99.98 1 PRPF8 99.98 1 PRPH2 99.98 1 PRPS1 99.95 1 RAB28 99.97 1 RAX2 100.00 1 RB1 99.84 1 RBP3 99.99 1 RBP4 99.99 1 RCBTB1 99.99 1 RD3 100.00 1 RDH11 99.99 1 RDH12 99.98 1 RDH5 100.00 1 REEP6 100.00 1 RGR 99.79 1 RGS9BP 100.00 1 RHO 100.00 1 RIMS1 99.85 1 RIMS2 99.97 1 RLBP1 99.99 1 ROM1 100.00 1 MAPRE2 99.98 1 RP1L1 100.00 1 RP2 99.58 1 RP9 99.83 1 RPE65 98.99 1 RPGR 94.45 1 RPGRIP1 99.95 1 RPGRIP1L 96.35 1 RS1 99.92 1 RTN4IP1 99.98 1 SAG 99.98 1 SAMD11 100.00 1 SAMD7 99.99 1 SCAPER 99.75 1 SCLT1 95.17 1 SDCCAG8 100.00 1 SEMA4A 99.81 1 SF3B2 99.98 1 SLC24A1 99.92 1 SLC25A46 99.88 1 SLC6A6 99.98 1 SLC7A14 99.99 1 SNRNP200 99.60 1 SPATA7 99.80 1 GPKOW 100.00 1 TEAD1 99.97 1 TIMM8A 100.00 1 TIMP3 100.00 1 TLR3 99.99 1 TLR4 99.99 1 TMEM126A 99.88 1 TMEM216 99.98 1 TMEM237 99.30 1 TOPORS 99.99 1 TREX1 100.00 1 TRIM32 100.00 1 TRNT1 99.97 1 TRPM1 99.96 1 TSPAN12 99.89 1 TTC8 99.67 1 TTLL5 99.95 1 TTPA 99.88 1 TUB 100.00 1 TUBGCP4 99.80 1 TUBGCP6 100.00 1 TULP1 99.99 1 UNC119 100.00 1 USH1C 99.99 1 USH1G 100.00 1 USH2A 99.88 1 VCAN 99.99 1 WDPCP 99.87 1 WDR19 99.80 1 WFS1 99.99 1 WHRN 99.96 1 ZNF408 99.99 1 ZNF423 98.94 1 ZNF513 99.97 1 -
Stroke - UGent
Gene % of coding sequence sufficiently covered to detect heterozygous mutations Copy number variation Comments ABCA1 99.92 1 ABCC6 98.57 1 ACAD9 100.00 1 ACP5 100.00 1 ACTA2 99.99 1 ACVRL1 99.88 1 ADA2 100.00 1 APP 99.92 1 ASS1 77.52 1 ATP7A 99.87 1 C1R 99.99 1 CACNA1A 98.16 1 CBS 17.79 1 CCM2 99.93 1 CD59 100.00 1 COG6 99.86 1 COL1A1 99.90 1 COL3A1 99.87 1 COL4A1 99.99 1 COL4A2 99.98 1 COL5A1 99.99 1 COL5A2 99.86 1 COQ8A 100.00 1 CYP21A2 99.91 1 CST3 100.00 1 CTSA 99.98 1 DYRK1B 99.99 1 EFEMP2 99.94 1 ENG 100.00 1 ENPP1 99.88 1 ESCO2 99.92 1 F10 99.98 1 F13A1 99.43 1 F2 99.99 1 F5 99.59 1 F7 100.00 1 F8A1 21.76 1 FBN1 99.85 1 FGA 99.98 1 FGB 99.93 1 FGG 99.98 1 FOXC1 100.00 1 GAA 100.00 1 GATA3 99.96 1 GCDH 100.00 1 GGCX 99.88 1 GLA 99.90 1 GUCY1A1 99.99 1 HBB 100.00 1 HSD11B2 99.99 1 HTRA1 100.00 1 ITM2B 99.85 1 IVD 100.00 1 JAG1 100.00 1 JAK2 99.52 1 JAM3 100.00 1 KNG1 99.99 1 KRIT1 99.33 1 LMNA 99.96 1 MFAP5 99.96 1 MFN2 99.98 1 MMACHC 99.98 1 MMUT 99.68 1 MTHFR 99.97 1 MYH11 99.16 1 NF1 99.88 1 NOTCH3 99.99 1 OTC 99.42 1 PCCA 99.90 1 PCCB 99.97 1 PCNT 99.97 1 PDCD10 99.94 1 PDE3A 99.97 1 PKD1 99.98 1 PLG 99.89 1 PLOD1 99.93 1 PLOD3 99.89 1 PROC 99.98 1 PROS1 99.84 1 PTPN11 99.98 1 RASA1 99.05 1 SAMHD1 99.98 1 SERPINE1 99.90 1 SLC19A2 98.86 1 SLC2A10 100.00 1 SMAD3 99.99 1 SMAD4 99.97 1 SMARCAL1 99.97 1 SPARC 99.94 1 STAT1 99.83 1 STIM1 99.99 1 TGFB2 99.87 1 TGFB3 100.00 1 TGFBR1 99.94 1 TGFBR2 99.98 1 THBD 100.00 1 TREX1 100.00 1 TSC1 99.99 1 TSC2 99.98 1 TTR 100.00 1 VHL 100.00 1 YY1AP1 99.98 1