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Dyskeratosis congenita

Disease Export to PDF
Name:
Dyskeratosis congenita
Description:
A rare ectodermal dysplasia syndrome that often presents with the classic triad of nail dysplasia, skin pigmentary changes, and oral leukoplakia associated with a high risk of bone marrow failure (BMF) and cancer.
ORPHAcode:
1775
Synonyms:
DC
DKC
Zinsser-Engman-Cole syndrome
XREF(s):
Orphanet
OMIM
OMIM
OMIM
OMIM
OMIM
OMIM
OMIM
OMIM
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OMIM
MeSH
MedDRA
ICD-10
Analyte(s):
NPM1
DKC1
TERT
TERC
TINF2
NOP10
NHP2
USB1
WRAP53
CTC1
RTEL1
PARN
TYMS
Created:
13 May 2019 - 01:02
Changed:
22 Jun 2023 - 16:14
  • Dyskeratosis Congenita (18 genes) - KUL
    Gene % of coding sequence sufficiently covered to detect heterozygous mutations Copy number variation Comments
    ACD 95.00 0 NM_001082486.1/ interpretable range CS1>95%
    CTC1 95.00 0 NM_025099.5/ interpretable range CS1>95%
    DKC1 95.00 0 NM_001363.4/ interpretable range CS1>95%
    GRHL2 95.00 0 NM_024915.3/ interpretable range CS1>95%
    LIG4 95.00 0 NM_002312.3/ interpretable range CS1>95%
    TNIP1 95.00 0 NM_138386.2/ interpretable range CS1>95%
    NHP2 95.00 0 NM_017838.3/ interpretable range CS1>95%
    NOP10 95.00 0 NM_018648.3/ interpretable range CS1>95%
    PARN 95.00 0 NM_002582.3/ interpretable range CS1>95%
    POT1 95.00 0 NM_015450.2/ interpretable range CS1>95%
    RTEL1 95.00 0 NM_032957.4/ interpretable range CS1>95%
    STN1 95.00 0 NM_024928.4/ interpretable range CS1>95%
    TERC 95.00 0 NR_001566.1/ interpretable range CS1>95%
    TERT 95.00 0 NM_198253.2/ interpretable range CS1>90%
    TINF2 95.00 0 NM_001099274.1/ interpretable range CS1>95%
    USB1 95.00 0 NM_024598.3/ interpretable range CS1>95%
    WRAP53 95.00 0 NM_018081.2/ interpretable range CS1>95%
    NAF1 95.00 0 NM_138386.3/ interpretable range CS1>95%