- Analytes
- TP53
TP53
Name: |
tumor protein p53
|
Symbol: |
TP53
|
Version of Orphanet: |
2023-06-22 14:14:43
|
Synonyms: |
LFS1
Li-Fraumeni syndrome
P53
p53
|
XREF(s): | |
Created: |
13 May 2019 - 01:01
|
Changed: |
26 Oct 2023 - 23:49
|
- Adenomatous polyposis, familial (gene panel)
- Breast and Ovarian Cancer, HBOC, Familial (17 genes)
- Breast and Ovarian Cancer, HBOC, Familial (gene panel)
- Breast and Ovarian Cancer, HBOC, Hereditary
- Breast and Ovarian Cancer, hereditary, HBOC, Familial (gene panel)
- Breast and Ovarian cancer, HBOC, familial (gene panel - 17 genes)
- Breast cancer, hereditary (gene panel)
- Colorectal cancer / Polyposis (gene panel)
- Congenital structural heart defects (gene panel)
- Familial cancer predisposition (gene panel)
- Gastric Cancer (10 genes)
- Hereditary Breast and Ovarian Cancer, HBOC (13 genes)
- Hereditary cancer (Breast, ovary, colon) (26 genes)
- Hereditary cancer (gene panel)
- Hereditary cancer panel (gene panel)
- Hereditary nonpolyposis colorectal cancer (gene panel)
- Hereditary nonpolyposis colorectal cancer / Lynch syndrome (8 genes)
- Li-Fraumeni Syndrome
- Li-Fraumeni Syndrome
- Li-Fraumeni Syndrome (TP53 gene)
- Li-Fraumeni syndrome
- Maffucci syndrome (gene panel)
- Medulloblastoma (gene panel)
- Myeloid neoplasms with germline predisposition (Hereditary MDS/Acute Leukemia) (gene panel)
- Overgrowth & vascular anomalies (gene panel)
- Pancreatic cancer (12 genes)
- Pancreatic cancer (gene panel)
- Pancreatic cancer, familial (gene panel)
- Pediatric oncopredisposition (gene panel)
- Rhabdomyosarcoma
- Sturge-Weber syndrome (gene panel)
- « Inherited bone marrow failures syndromes » with or without organ dysfunction
- Adrenocortical carcinoma
- Adult hepatocellular carcinoma
- Alveolar rhabdomyosarcoma
- B-cell chronic lymphocytic leukemia
- B-lymphoblastic leukemia/lymphoma with recurrent genetic abnormality
- B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)
- Choroid plexus carcinoma
- Cushing disease
- Embryonal rhabdomyosarcoma
- Essential thrombocythemia
- Familial pancreatic carcinoma
- Giant cell glioblastoma
- Gliosarcoma
- Hereditary breast and/or ovarian cancer syndrome
- Li-Fraumeni syndrome
- Osteosarcoma
- Papilloma of choroid plexus
- Pleomorphic rhabdomyosarcoma
- Precursor B-cell acute lymphoblastic leukemia
- Small cell lung cancer
-
Extended Breast Cancer Panel (26 gene) - VUB
Gene % of coding sequence sufficiently covered to detect heterozygous mutations Copy number variation Comments ATM 100.00 1 No comment BARD1 100.00 1 No comment BLM 100.00 1 No comment BRCA1 100.00 1 No comment BRCA2 100.00 1 No comment BRIP1 100.00 1 No comment CDH1 100.00 1 No comment CHEK2 100.00 1 No comment EPCAM 100.00 1 No comment ABRAXAS1 100.00 1 No comment MEN1 100.00 1 No comment MLH1 100.00 1 No comment MRE11 100.00 1 No comment MSH2 100.00 1 No comment MSH6 100.00 1 No comment MUTYH 100.00 1 No comment NBN 100.00 1 No comment PALB2 100.00 1 No comment PMS2 100.00 1 No comment PTEN 100.00 1 No comment RAD50 100.00 1 No comment RAD51C 100.00 1 No comment RAD51D 100.00 1 No comment STK11 100.00 1 No comment TP53 100.00 1 No comment XRCC2 100.00 1 No comment -
Breast and ovarian cancer - UGent
Gene % of coding sequence sufficiently covered to detect heterozygous mutations Copy number variation Comments ATM 100.00 1 BARD1 100.00 1 BRCA1 100.00 1 BRCA2 100.00 1 BRIP1 100.00 1 CHEK2 100.00 1 MLH1 100.00 1 MSH2 100.00 1 MSH6 100.00 1 PALB2 100.00 1 RAD51C 100.00 1 RAD51D 100.00 1 TP53 100.00 1 -
Breast cancer, hereditary (13 genes) - ULG
Gene % of coding sequence sufficiently covered to detect heterozygous mutations Copy number variation Comments BRCA1 100.00 1 CNV assessed by MLPA BRCA2 100.00 1 CNV assessed by MLPA TP53 100.00 1 CNV assessed by MLPA (on demand) PALB2 100.00 0 CHEK2 100.00 0 BARD1 100.00 0 ATM 100.00 0 MLH1 100.00 1 CNV assessed by MLPA (on demand) MSH2 100.00 1 CNV assessed by MLPA (on demand) MSH6 100.00 1 CNV assessed by MLPA (on demand) BRIP1 100.00 0 RAD51C 100.00 0 RAD51D 100.00 0 -
Breast/ ovarian cancer (12 genes) - UZA
Gene % of coding sequence sufficiently covered to detect heterozygous mutations Copy number variation Comments BRCA1 BRCA2 PALB2 TP53 CHEK2 ATM BRIP1 RAD51C RAD51D MLH1 MSH2 MSH6 -
Breast/ ovarian cancer (15 genes) - KUL
Gene % of coding sequence sufficiently covered to detect heterozygous mutations Copy number variation Comments RAD51C 100.00 1 RAD51D 100.00 1 BRCA1 100.00 1 BRCA2 100.00 1 TP53 100.00 1 CHEK2 100.00 1 MLH1 100.00 1 MSH2 100.00 1 MSH6 100.00 1 BRIP1 100.00 1 ATM 100.00 1 PALB2 100.00 1 CDH1 100.00 1 BARD1 100.00 1 PTEN 100.00 1 -
Breast/Ovarian cancer (17 genes) - ULB
Gene % of coding sequence sufficiently covered to detect heterozygous mutations Copy number variation Comments BRCA1 100.00 1 Core gene BRCA2 100.00 1 Core gene TP53 100.00 1 Core gene PALB2 100.00 1 Core gene CHEK2 100.00 1 Core gene for c.1100delC ATM 100.00 1 BARD1 100.00 1 BRIP1 100.00 1 CDH1 100.00 1 EPCAM 100.00 1 ABRAXAS1 100.00 1 MLH1 100.00 1 MRE11 100.00 1 MSH2 100.00 1 MSH6 100.00 1 MUTYH 100.00 1 NBN 100.00 1 PIK3CA 100.00 1 PMS2 100.00 1 PMS2CL 100.00 1 PTEN 100.00 1 RAD50 100.00 1 RAD51C 100.00 1 RAD51D 100.00 1 STK11 100.00 1 XRCC2 100.00 1 -
Breast/ovarian cancer (12 genes) - UCL
Gene % of coding sequence sufficiently covered to detect heterozygous mutations Copy number variation Comments BRCA1 BRCA2 TP53 PALB2 CHEK2 ATM BRIP1 RAD51C RAD51D MLH1 MSH2 MSH6 -
Cancer (Breast, ovary, colon,…) (26 genes) - ULG
Gene % of coding sequence sufficiently covered to detect heterozygous mutations Copy number variation Comments ABRAXAS1 ATM BARD1 BRCA1 BRCA2 BLM BRIP1 CDH1 CHEK2 EPCAM MEN1 MLH1 MRE11 MSH2 MSH6 MUTYH NBN PALB2 PMS2 PTEN RAD50 RAD51C RAD51D STK11 TP53 XRCC2 -
Colorectal cancer/polyposis (18 genes) - KUL
Gene % of coding sequence sufficiently covered to detect heterozygous mutations Copy number variation Comments MLH1 100.00 1 MSH2 100.00 1 MSH6 100.00 1 PMS2 100.00 1 EPCAM 100.00 1 POLD1 100.00 1 POLE 100.00 1 CHEK2 100.00 1 TP53 100.00 1 APC 100.00 1 STK11 100.00 1 BMPR1A 100.00 1 SMAD4 100.00 1 PTEN 100.00 1 RNF43 100.00 1 NTHL1 100.00 1 MSH3 100.00 1 MUTYH 100.00 1 -
Congenital structural heart defects - UGent
Gene % of coding sequence sufficiently covered to detect heterozygous mutations Copy number variation Comments AATK 99.98 1 ABL1 100.00 1 ACAN 91.51 1 ACTA1 99.99 1 ACTB 100.00 1 ACTC1 98.57 1 ACTG1 100.00 1 ACTN2 99.99 1 ACVR1 99.94 1 ACVR1B 99.99 1 ACVR2A 99.15 1 ACVR2B 99.99 1 ACVRL1 99.88 1 ADAMTS10 99.99 1 ADNP 100.00 1 AKAP12 100.00 1 AKT1 100.00 1 AKT2 99.85 1 ALDH1A2 99.97 1 ALX3 99.74 1 ANKRD1 99.57 1 ANKRD11 99.85 1 AP1B1 99.99 1 APAF1 98.70 1 AR 99.76 1 ARHGAP31 100.00 1 ARID4A 99.90 1 ATP2A2 99.98 1 ATRX 99.44 1 AXIN1 100.00 1 BCOR 99.97 1 BMP10 99.96 1 BMP2 99.79 1 BMP4 100.00 1 BMP6 100.00 1 BMP7 100.00 1 BMPR1A 99.58 1 BMPR2 99.95 1 BRAF 99.78 1 BRIP1 99.39 1 BVES 99.83 1 CASQ2 94.39 1 CAV1 99.97 1 CAV3 100.00 1 CBL 99.95 1 CCDC103 99.68 1 CCDC39 99.74 1 CCDC40 100.00 1 CCDC65 99.80 1 CCN1 99.99 1 CCNO 100.00 1 CD96 99.91 1 CDK13 99.83 1 CDK4 100.00 1 CDX2 100.00 1 CENPF 99.97 1 CFAP53 99.95 1 CFC1 21.93 1 CHAC2 99.68 1 CHD4 99.99 1 CHD7 99.99 1 CHD8 99.96 1 CITED2 100.00 1 COL1A1 99.90 1 COL1A2 99.34 1 COL2A1 99.87 1 COX7B 99.86 1 CREBBP 99.97 1 CRELD1 99.99 1 CRIP2 99.99 1 CRYAB 100.00 1 CSNK1D 99.99 1 CSRP1 99.75 1 CSRP3 100.00 1 CTNNB1 99.95 1 DDX3X 99.01 1 DES 100.00 1 DIAPH3 99.85 1 DICER1 99.96 1 DLGAP5 99.83 1 DLL1 99.99 1 DLL4 100.00 1 DNAAF1 99.99 1 DNAAF11 99.80 1 DNAAF2 99.91 1 DNAAF3 99.99 1 DNAAF4 99.78 1 DNAAF5 99.99 1 DNAH11 99.93 1 DNAH5 99.98 1 DNAI1 99.92 1 DNAI2 99.86 1 DNAJB13 99.91 1 DNAH9 99.79 1 DRC1 99.93 1 DSCAM 99.99 1 DVL1 100.00 1 DYRK1A 99.98 1 E2F1 99.99 1 ECE1 99.92 1 EDNRA 99.97 1 EFEMP2 99.94 1 EFNB1 99.95 1 EFTUD2 99.93 1 EGFR 99.68 1 EGR1 99.99 1 EHMT1 98.38 1 ELN 99.86 1 ENG 100.00 1 EOGT 99.09 1 EP300 99.97 1 EPHB2 99.86 1 EPHB4 99.82 1 ERBB2 99.98 1 ERCC4 99.92 1 ESR2 99.96 1 ETS1 99.99 1 EVC 99.95 1 EVC2 99.97 1 EWSR1 99.94 1 EZH2 99.89 1 F2R 99.98 1 FABP3 99.87 1 FADD 99.97 1 FANCA 100.00 1 FANCB 99.24 1 FANCC 99.98 1 FANCD2 99.86 1 FANCE 99.99 1 FANCF 100.00 1 FANCG 100.00 1 FANCI 99.96 1 FANCL 99.67 1 FBLN1 98.69 1 FBLN7 99.95 1 FBN1 99.85 1 FBN2 99.90 1 FGF10 99.95 1 FGF8 100.00 1 FGFR1 100.00 1 FGFR2 99.99 1 FGFR3 100.00 1 FHL2 100.00 1 FIBP 99.83 1 FLII 100.00 1 FLNA 99.99 1 FLNC 99.99 1 FLT1 99.99 1 FLT4 97.93 1 FN1 99.95 1 FOXC1 100.00 1 FOXC2 100.00 1 FOXH1 100.00 1 FOXK2 99.76 1 FOXL1 100.00 1 FOXL2 99.97 1 FOXO1 100.00 1 FOXP1 99.98 1 FSCN2 100.00 1 G6PC3 99.98 1 GAS8 100.00 1 GATA2 99.99 1 GATA4 99.99 1 GATA5 100.00 1 GATA6 99.90 1 GATAD2B 99.44 1 GDF1 100.00 1 GDF11 99.97 1 GDF5 100.00 1 GDNF 99.99 1 GJA1 100.00 1 GJA5 100.00 1 GJD2 99.99 1 GLB1 100.00 1 GLI2 99.93 1 GLI3 100.00 1 GPC3 99.60 1 GPC5 99.96 1 GPC6 99.98 1 GRK5 99.97 1 GTF2I 47.18 1 GTF2IRD1 99.77 1 HAND1 99.99 1 HAND2 99.97 1 HDAC8 99.74 1 HES4 100.00 1 HEY2 99.75 1 HIF1A 99.87 1 HMGB2 99.99 1 HNF1A 100.00 1 HNF4A 100.00 1 HOXA1 100.00 1 HOXB2 99.99 1 HRAS 100.00 1 HSPB1 99.97 1 HSPB8 100.00 1 HSPG2 99.87 1 HYDIN 81.28 1 ID2 100.00 1 IGF1R 100.00 1 IGFBP4 99.85 1 IKBKB 99.93 1 ILK 100.00 1 INHBA 99.98 1 INHBC 99.99 1 INPP5D 99.98 1 INSR 99.99 1 IRS1 100.00 1 IRX4 99.99 1 ISL1 99.99 1 ITGAV 99.40 1 ITGB1 99.96 1 ITGB3 99.83 1 ITGB4 99.99 1 JAG1 100.00 1 JAM3 100.00 1 JUN 100.00 1 KANSL1 99.85 1 KAT6A 99.93 1 KAT6B 99.79 1 KDM3B 99.98 1 KDM5A 99.90 1 KDM5B 97.15 1 KDM6A 99.74 1 KDR 99.86 1 KIT 99.86 1 KMT2D 99.98 1 KRAS 99.13 1 KREMEN1 99.88 1 LAMA2 99.95 1 LAMA5 99.99 1 LAMC1 99.55 1 LBR 99.66 1 LEFTY1 99.98 1 LEFTY2 100.00 1 LHX3 99.99 1 LMNA 99.96 1 LMX1B 100.00 1 LRP2 99.86 1 LTBP1 99.95 1 LTBP3 99.96 1 LZTR1 99.46 1 MAFG 100.00 1 MAP2K1 99.98 1 MAP2K2 99.99 1 MAPK14 99.95 1 MCTP2 99.99 1 MECOM 99.97 1 MED13L 99.99 1 MEF2C 99.57 1 MEGF8 99.90 1 MESP1 100.00 1 MET 99.97 1 METTL3 99.98 1 MGP 99.95 1 MID1 99.90 1 MITF 99.98 1 MMP2 99.96 1 MMP21 99.99 1 MSX1 100.00 1 MTHFD1 100.00 1 MTHFR 99.97 1 MTRR 99.98 1 MYBPC3 99.98 1 MYC 100.00 1 MYH10 99.91 1 MYH11 99.16 1 MYH6 100.00 1 MYH7 99.99 1 MYH9 99.95 1 MYL2 99.99 1 MYL3 99.99 1 MYL7 99.95 1 MYOCD 99.99 1 MYOM1 99.98 1 MYOZ2 99.99 1 NF1 99.88 1 NFATC1 100.00 1 NFIX 99.99 1 NFKB1 99.80 1 NID2 99.97 1 NIPBL 99.34 1 NKX2-1 100.00 1 NKX2-5 99.75 1 NKX2-6 100.00 1 NME8 99.83 1 NNMT 100.00 1 NODAL 99.98 1 NONO 99.94 1 NOS3 93.73 1 NOTCH1 99.98 1 NOTCH2 99.03 1 NOTCH3 99.99 1 NPHP3 99.89 1 NPHP4 99.98 1 NPPA 100.00 1 NR2F2 100.00 1 NR4A2 99.97 1 NRAS 99.66 1 NRP1 99.99 1 NRP2 99.98 1 NSD1 99.98 1 ODAD1 96.04 1 ODAD2 98.19 1 ODAD3 99.96 1 ODAD4 99.85 1 OTX2 100.00 1 PACS1 99.96 1 PAX3 100.00 1 PCSK5 99.97 1 PDGFC 99.97 1 PDGFRA 99.94 1 PDGFRB 99.99 1 PDHX 100.00 1 PIGA 99.81 1 PIGL 99.98 1 PIGN 99.91 1 PIGT 99.95 1 PITX2 99.98 1 PKD1L1 99.84 1 PLAGL1 99.96 1 PLAT 99.99 1 POU5F1 100.00 1 PPARG 99.96 1 PPARGC1A 99.82 1 PPP3CA 99.84 1 PRKACA 99.95 1 PRKD1 99.96 1 PROX1 99.98 1 PRRX1 99.56 1 PSEN1 100.00 1 PSEN2 99.97 1 PTEN 99.89 1 PTK2 99.97 1 PTP4A3 99.99 1 PTPN11 99.98 1 PUF60 100.00 1 RAB23 99.97 1 RAD21 99.91 1 RAD51C 99.02 1 RAF1 99.97 1 RAI1 99.22 1 RAI2 99.98 1 RARB 99.99 1 RARG 99.98 1 RB1 99.84 1 RBBP7 99.87 1 RBL2 99.44 1 RBM10 99.98 1 RBM8A 99.37 1 RELA 99.99 1 RERE 99.94 1 RET 99.97 1 RGS19 99.88 1 RIT1 99.78 1 RNF20 99.93 1 ROR2 99.99 1 RPGR 94.45 1 RPL11 99.81 1 RPL15 31.77 1 RPL26 30.55 1 RPL35A 97.55 1 RPL5 28.81 1 RPS10 0.00 1 RPS17 100.00 1 RPS19 100.00 1 RPS24 91.48 1 RPS26 8.99 1 RPS28 100.00 1 RPS29 99.96 1 RPS7 88.50 1 RSPH1 99.87 1 RSPH3 99.94 1 RSPH4A 99.95 1 RSPH9 99.99 1 RYR2 99.94 1 SALL1 100.00 1 SALL4 100.00 1 SCN5A 100.00 1 SESN1 99.95 1 SF3B4 99.65 1 SGCA 100.00 1 SH3PXD2B 100.00 1 SHH 100.00 1 SHOC2 99.96 1 HHAT 99.98 1 SLC19A1 99.99 1 SLC25A4 100.00 1 SLC2A10 100.00 1 SLX4 100.00 1 SMAD2 99.92 1 SMAD3 99.99 1 SMAD4 99.97 1 SMAD6 100.00 1 SMARCE1 99.87 1 SMC1A 99.98 1 SMC3 99.91 1 SMG9 99.99 1 SOS1 99.68 1 SOS2 99.39 1 SOX2 100.00 1 SOX4 99.36 1 SP1 99.98 1 SPAG1 99.78 1 SPATC1L 99.99 1 SPECC1L 99.98 1 SRCAP 99.99 1 SRF 99.99 1 STAT3 99.97 1 STRA6 99.95 1 SUZ12 98.58 1 TAB2 99.75 1 TBX1 99.95 1 TBX2 99.97 1 TBX20 99.99 1 TBX3 100.00 1 TBX5 99.98 1 TBX6 99.99 1 TCAP 100.00 1 TCF21 100.00 1 TCF3 100.00 1 TCN2 100.00 1 CRIPTO 99.82 1 TEAD1 99.97 1 TEK 99.98 1 TFAP2A 100.00 1 TFAP2B 99.98 1 TFAP2C 100.00 1 TGFB1 100.00 1 TGFB2 99.87 1 TGFB3 100.00 1 TGFBR1 99.94 1 TGFBR2 99.98 1 TGIF1 100.00 1 THBS1 100.00 1 THBS4 100.00 1 THOC5 99.90 1 THRB 99.82 1 DDR2 97.39 1 TLL1 99.94 1 TNFRSF11A 100.00 1 TNFRSF1A 100.00 1 TNNI3 100.00 1 TNNT2 99.87 1 TNR 99.80 1 TP53 99.98 1 TP73 100.00 1 TPM1 99.92 1 TRPM2 99.99 1 TSR2 99.96 1 TTN 99.15 1 TWIST1 100.00 1 UBE2B 99.94 1 UBE2T 99.89 1 USP44 99.86 1 USP9X 99.84 1 VCAN 99.99 1 VDR 99.86 1 VEGFA 99.99 1 VEGFC 99.96 1 WASHC5 99.98 1 WDR5 100.00 1 WNT11 100.00 1 WT1 99.99 1 YY1 100.00 1 ZEB2 99.97 1 ZFHX3 99.96 1 ZFPM2 100.00 1 ZIC3 99.90 1 ZMYND10 99.99 1 -
Familial pancreatic cancer
Gene % of coding sequence sufficiently covered to detect heterozygous mutations Copy number variation Comments ATM 100.00 1 BRCA1 100.00 1 BRCA2 100.00 1 CDKN2A 100.00 1 MLH1 100.00 1 MSH2 100.00 1 MSH6 100.00 1 PALB2 100.00 1 PMS2 100.00 1 RABL3 100.00 0 STK11 100.00 1 TP53 100.00 1 -
Gastric cancer (10 genes) - KUL
Gene % of coding sequence sufficiently covered to detect heterozygous mutations Copy number variation Comments APC 100.00 1 CDH1 100.00 1 TP53 100.00 1 BRCA1 100.00 1 BRCA2 100.00 1 EPCAM 100.00 1 MLH1 100.00 1 MSH2 100.00 1 MSH6 100.00 1 PMS2 100.00 1 -
Hematologic Familiar Forms - ULG
Gene % of coding sequence sufficiently covered to detect heterozygous mutations Copy number variation Comments RPS7 88.11 0 No CHEK2 80.48 0 No PTPN11 95.76 0 No KRAS 96.88 0 No RPS10 98.48 0 No FANCM 97.86 0 No RPL35A 98.16 0 No RPS24 98.39 0 No ANKRD26 100.00 0 Genomic start 27389256 to genomic end 27389427 UTR position RPL5 96.83 0 No SHQ1 97.53 0 No RPS26 98.64 0 No SRP72 97.98 0 No FANCL 98.99 0 No EGLN1 98.71 0 No JAK2 97.81 0 No DNAJC21 98.55 0 No NF1 96.15 0 No BLM 98.77 0 No SBF2 99.19 0 No MSH2 98.36 0 No ATM 98.90 0 No ERCC4 98.33 0 No RPL11 99.02 0 No NBN 99.57 0 No PMS2 98.87 0 No ATG2B 99.33 0 No BRCA2 99.11 0 No ERCC6L2 99.48 0 No ATR 99.19 0 No VPS45 99.60 0 No SRP54 99.44 0 No SBDS 96.51 0 No UBE2T 98.01 0 No RBM8A 99.34 0 No RAD51C 99.83 0 No FANCC 99.72 0 No FANCD2 99.00 0 No BRIP1 99.61 0 No BRCA1 99.80 0 No CEBPA 99.48 0 No PARN 99.84 0 No MSH6 99.84 0 No MECOM 99.83 0 No PALB2 99.80 0 No FANCE 97.83 0 No PAX5 99.72 0 No RAD51 99.94 0 No ATRX 99.85 0 No FANCB 99.61 0 No FANCI 99.66 0 No STN1 99.75 0 No NHP2 99.79 0 No MLH1 99.86 0 No TERT 100.00 0 Genomic start 1295105 to genomic end 1295162 UTR position XRCC2 99.97 0 No FANCA 99.93 0 No EPAS1 99.62 0 No TET2 99.97 0 No HAX1 99.98 0 No SLX4 99.98 0 No CBL 99.87 0 No WAS 99.90 0 No USB1 100.00 0 No EPO 99.99 0 No VHL 99.98 0 No MAD2L2 100.00 0 No RUNX1 99.94 0 No CTC1 99.99 0 No GSKIP 99.99 0 No DKC1 100.00 0 Genomic start 153991031 to genomic end 153991240 UTR position SAMD9L 99.96 0 No MPL 99.99 0 No ETV6 100.00 0 No LIG4 99.98 0 No NOP10 99.99 0 No G6PC3 100.00 0 No CSF3R 100.00 0 No SAMD9 100.00 0 No ELANE 100.00 0 No GATA2 100.00 0 No RPS19 100.00 0 No GFI1 100.00 0 No FANCF 100.00 0 No TPP1 99.99 0 No FANCG 100.00 0 No WRAP53 100.00 0 No TP53 100.00 0 No TINF2 100.00 0 No EPOR 100.00 0 No DDX41 100.00 0 No THPO 100.00 0 No TERC 100.00 0 Genomic start 169482849 to genomic end 169483098 UTR position RTEL1 100.00 0 Genomic start 62326911 to genomic end 62326911 and genomic start 62326900 to genomic end 62326928 and genomic start 62326958 to genomic end 62326986 intronic positions and 99.98 for CDS -
Hereditary Cancer Solution (35 genes) - UCL
Gene % of coding sequence sufficiently covered to detect heterozygous mutations Copy number variation Comments APC 100.00 1 ISO15189 ATM 100.00 1 ISO15189 BAP1 100.00 1 ISO15189 BARD1 100.00 1 ISO15189 BMPR1A 100.00 1 ISO15189 BRCA1 100.00 1 ISO15189 BRCA2 100.00 1 ISO15189 BRIP1 100.00 1 ISO15189 CDH1 100.00 1 ISO15189 CDKN2A 100.00 1 ISO15189 CHEK2 100.00 1 ISO15189 EPCAM 100.00 1 ISO15189 GREM1 100.00 1 ISO15189 MLH1 100.00 1 ISO15189 MRE11 100.00 1 ISO15189 MSH2 100.00 1 ISO15189 MSH3 100.00 1 ISO15189 MSH6 100.00 1 ISO15189 MUTYH 100.00 1 ISO15189 NBN 100.00 1 ISO15189 NTHL1 100.00 1 ISO15189 PALB2 100.00 1 ISO15189 PIK3CA 100.00 1 ISO15189 PMS2 100.00 1 ISO15189 POLD1 100.00 1 ISO15189 POLE 100.00 1 ISO15189 PTEN 100.00 1 ISO15189 RAD50 100.00 1 ISO15189 RAD51C 100.00 1 ISO15189 RAD51D 100.00 1 ISO15189 SCG5 100.00 1 ISO15189 SMAD4 100.00 1 ISO15189 STK11 100.00 1 ISO15189 TP53 100.00 1 ISO15189 XRCC2 100.00 1 ISO15189 -
Hereditary Myelodysplastic /Acute Leukemia Predisposition Syndromes (gene panel)
Gene % of coding sequence sufficiently covered to detect heterozygous mutations Copy number variation Comments CEBPA 100.00 0 Exon 1 ETV6 100.00 0 Exons 1-6 GATA1 100.00 0 Exons 2-6 GATA2 100.00 0 Exons 2-6 JAK2 100.00 0 Exons 12 and 14 MPL 100.00 0 Exon 10 RUNX1 100.00 0 Exons 1-6 ANKRD26 100.00 0 5’UTR CSF3R 100.00 0 exons 14 and17 DDX41 100.00 0 exons 3 ;5 ;6 ;8 ;10 ;11 ;15 SRP72 100.00 0 exons 4 and10 STAT3 100.00 0 exons 19-24 TERT 100.00 0 exons 2-9 TERC 100.00 0 exon 1 TP53 100.00 0 exons 2-11 -
Hereditary breast and ovarian cancer (26 genes) - CHULg
Gene % of coding sequence sufficiently covered to detect heterozygous mutations Copy number variation Comments ATM 100.00 -2 BARD1 100.00 -2 BLM 100.00 -2 BRCA1 100.00 -2 BRCA2 100.00 -2 BRIP1 100.00 -2 CDH1 100.00 -2 CHEK2 100.00 -2 EPCAM 100.00 -2 ABRAXAS1 100.00 -2 MEN1 100.00 -2 MLH1 100.00 -2 MRE11 100.00 -2 MSH2 100.00 -2 MSH6 100.00 -2 MUTYH 100.00 -2 NBN 100.00 -2 PALB2 100.00 -2 PMS2 100.00 -2 PTEN 100.00 -2 RAD50 100.00 -2 RAD51C 100.00 -2 RAD51D 100.00 -2 STK11 100.00 -2 TP53 100.00 -2 XRCC2 100.00 -2 -
Hereditary cancer predisposition - UGent
Gene % of coding sequence sufficiently covered to detect heterozygous mutations Copy number variation Comments ABRAXAS1 100.00 0 ACD 100.00 0 AIP 100.00 0 AMER1 100.00 0 APC 100.00 0 ATM 100.00 0 AXIN2 100.00 0 BAP1 100.00 0 BARD1 100.00 0 BLM 100.00 0 BMPR1A 100.00 0 BRCA1 100.00 0 BRCA2 100.00 0 BRIP1 100.00 0 BUB1B 100.00 0 BUB3 100.00 0 CDH1 100.00 0 CDK12 100.00 0 CDK4 100.00 0 CDKN1B 100.00 0 CDKN2A 100.00 0 CHEK1 100.00 0 CHEK2 100.00 0 CTNNA1 100.00 0 CTNNB1 100.00 0 DICER1 100.00 0 EDN3 100.00 0 EDNRB 100.00 0 EPCAM 100.00 0 ERCC4 100.00 0 FANCA 100.00 0 FANCB 100.00 0 FANCC 100.00 0 FANCD2 100.00 0 FANCE 100.00 0 FANCF 100.00 0 FANCG 100.00 0 FANCI 100.00 0 FANCL 100.00 0 FANCM 100.00 0 FH 100.00 0 FLCN 100.00 0 GDNF 100.00 0 GREM1 100.00 0 HNF1B 100.00 0 HOXB13 100.00 0 MAD2L2 100.00 0 MAX 100.00 0 MEN1 100.00 0 MET 100.00 0 MITF 100.00 0 MLH1 100.00 0 MRE11 100.00 0 MSH2 100.00 0 MSH3 100.00 0 MSH6 100.00 0 MUTYH 100.00 0 NBN 100.00 0 NRG3 100.00 0 NRTN 100.00 0 NTHL1 100.00 0 PALB2 100.00 0 PALLD 100.00 0 PBRM1 100.00 0 PMS2 100.00 0 POLD1 100.00 0 POLE 100.00 0 POT1 100.00 0 PPP2R2A 100.00 0 PTEN 100.00 0 RABL3 100.00 0 RAD50 100.00 0 RAD51 100.00 0 RAD51B 100.00 0 RAD51C 100.00 0 RAD51D 100.00 0 RAD54L 100.00 0 RECQL 100.00 0 RET 100.00 0 RFWD3 100.00 0 RNF43 100.00 0 SDHA 100.00 0 SDHAF2 100.00 0 SDHB 100.00 0 SDHC 100.00 0 SDHD 100.00 0 SEMA3C 100.00 0 SEMA3D 100.00 0 SLX4 100.00 0 SMAD4 100.00 0 SMARCA4 100.00 0 SOX10 100.00 0 SPINK1 100.00 0 STK11 100.00 0 SUCLG2 100.00 0 TERF2IP 100.00 0 TERT 100.00 0 TMEM127 100.00 0 TP53 100.00 0 TSC1 100.00 0 TSC2 100.00 0 UBE2T 100.00 0 VHL 100.00 0 WT1 100.00 0 XRCC2 100.00 0 MBD4 100.00 0 NRG1 100.00 0 -
Hereditary predisposition to cancer (47 genes) - IPG
Gene % of coding sequence sufficiently covered to detect heterozygous mutations Copy number variation Comments APC 100.00 1 NM_000038.6 ATM 100.00 1 NM_000051.3 BAP1 100.00 1 NM_004656.4 BARD1 100.00 1 NM_000465.4 BMPR1A 100.00 1 NM_004329.3 BRCA1 100.00 1 NM_007294.4 BRCA2 100.00 1 NM_000059.3 BRIP1 100.00 1 NM_032043.3 CDH1 100.00 1 NM_004360.5 CDKN1B 100.00 1 NM_004064.4 CDKN2A 100.00 1 NM_001195132.1 CHEK2 100.00 1 NM_007194.4 EPCAM 100.00 1 NM_002354.3 GATA2 100.00 1 NM_032638.5 GREM1 100.00 1 NM_013372.7 MEN1 100.00 1 NM_001370259.2 MLH1 100.00 1 NM_000249.4 MSH2 100.00 1 NM_000251.3 MSH3 100.00 1 NM_002439.5 MSH6 100.00 1 NM_000179.3 MUTYH 100.00 1 NM_001128425.2 NBN 100.00 1 NM_002485.5 NTHL1 100.00 1 NM_002528.7 PALB2 100.00 1 NM_024675.4 PIK3CA 100.00 1 NM_006218.4 PMS2 100.00 1 NM_000535.7 POLD1 100.00 1 NM_002691.4 POLE 100.00 1 NM_006231.4 PTEN 100.00 1 NM_000314.8 RAD50 100.00 1 NM_005732.4 RAD51C 100.00 1 NM_058216.3 RAD51D 100.00 1 NM_002878.3 RPS20 100.00 1 NM_001146227.2 SCG5 100.00 1 NM_001144757.2 SMAD4 100.00 1 NM_005359.6 STK11 100.00 1 NM_000455.5 TP53 100.00 1 NM_000546.5 WWP1 100.00 1 NM_007013.4 AXIN2 100.00 1 NM_004655.4 CDK4 100.00 1 NM_000075.4 DICER1 100.00 1 NM_030621.4 HOXB13 100.00 1 NM_006361.6 NF1 100.00 1 NM_001042492.3 POT1 100.00 1 NM_015450.3 PTCH1 100.00 1 NM_000264.5 RB1 100.00 1 NM_000321.2 RET 100.00 1 NM_020975.6 -
Hereditay Non Polyposis Colorectal Cancer (8 genes) - ULG
Gene % of coding sequence sufficiently covered to detect heterozygous mutations Copy number variation Comments MLH1 100.00 1 CNV assessed by MLPA MSH2 100.00 1 CNV assessed by MLPA MSH6 100.00 1 CNV assessed by MLPA EPCAM 100.00 0 TP53 100.00 1 CNV assessed by MLPA MUTYH 100.00 1 CNV assessed by MLPA (on demand) POLE 100.00 0 POLD1 100.00 0 -
Maffucci syndrome (65 genes) - KUL
Gene % of coding sequence sufficiently covered to detect heterozygous mutations Copy number variation Comments ABL1 0.00 0 Only hotspots in the gene AKT1 0.00 0 Only hotspots in the gene ALK 0.00 0 Only hotspots in the gene APC 0.00 0 Only hotspots in the gene ATM 0.00 0 Only hotspots in the gene BRAF 0.00 0 Only hotspots in the gene BRCA1 0.00 0 Only hotspots in the gene BRCA2 0.00 0 Only hotspots in the gene CDH1 0.00 0 Only hotspots in the gene CDKN2A 0.00 0 Only hotspots in the gene CSF1R 0.00 0 Only hotspots in the gene CTNNB1 0.00 0 Only hotspots in the gene DDR2 0.00 0 Only hotspots in the gene DNMT3A 0.00 0 Only hotspots in the gene EGFR 0.00 0 Only hotspots in the gene ERBB2 0.00 0 Only hotspots in the gene ERBB3 0.00 0 Only hotspots in the gene ERBB4 0.00 0 Only hotspots in the gene EZH2 0.00 0 Only hotspots in the gene FBXW7 0.00 0 Only hotspots in the gene FGFR1 0.00 0 Only hotspots in the gene FGFR2 0.00 0 Only hotspots in the gene FGFR3 0.00 0 Only hotspots in the gene FLT3 0.00 0 Only hotspots in the gene FOXL2 0.00 0 Only hotspots in the gene GNA11 0.00 0 Only hotspots in the gene GNAQ 0.00 0 Only hotspots in the gene GNAS 0.00 0 Only hotspots in the gene HNF1A 0.00 0 Only hotspots in the gene HRAS 0.00 0 Only hotspots in the gene IDH1 0.00 0 Only hotspots in the gene IDH2 0.00 0 Only hotspots in the gene JAK2 0.00 0 Only hotspots in the gene JAK3 0.00 0 Only hotspots in the gene KDR 0.00 0 Only hotspots in the gene KIT 0.00 0 Only hotspots in the gene KRAS 0.00 0 Only hotspots in the gene MAP2K1 0.00 0 Only hotspots in the gene MET 0.00 0 Only hotspots in the gene MLH1 0.00 0 Only hotspots in the gene MPL 0.00 0 Only hotspots in the gene MSH6 0.00 0 Only hotspots in the gene MTOR 0.00 0 Only hotspots in the gene NF1 0.00 0 Only hotspots in the gene NF2 0.00 0 Only hotspots in the gene NOTCH1 0.00 0 Only hotspots in the gene NPM1 0.00 0 Only hotspots in the gene NRAS 0.00 0 Only hotspots in the gene PDGFRA 0.00 0 Only hotspots in the gene PIK3CA 0.00 0 Only hotspots in the gene PIK3R1 0.00 0 Only hotspots in the gene PTCH1 0.00 0 Only hotspots in the gene PTEN 0.00 0 Only hotspots in the gene PTPN11 0.00 0 Only hotspots in the gene RB1 0.00 0 Only hotspots in the gene RET 0.00 0 Only hotspots in the gene SMAD4 0.00 0 Only hotspots in the gene SMARCB1 0.00 0 Only hotspots in the gene SMO 0.00 0 Only hotspots in the gene SRC 0.00 0 Only hotspots in the gene STK11 0.00 0 Only hotspots in the gene TERT 0.00 0 Only hotspots in the gene TP53 0.00 0 Only hotspots in the gene TSC1 0.00 0 Only hotspots in the gene VHL 0.00 0 Only hotspots in the gene -
Medulloblastoma (3 genes) - KUL
Gene % of coding sequence sufficiently covered to detect heterozygous mutations Copy number variation Comments SUFU 100.00 1 TP53 100.00 1 PTCH1 100.00 1 -
Overgrowth & vascular anomalies (65 genes) - KUL
Gene % of coding sequence sufficiently covered to detect heterozygous mutations Copy number variation Comments ABL1 0.00 0 Only hotspots in the gene AKT1 0.00 0 Only hotspots in the gene ALK 0.00 0 Only hotspots in the gene APC 0.00 0 Only hotspots in the gene ATM 0.00 0 Only hotspots in the gene BRAF 0.00 0 Only hotspots in the gene BRCA1 0.00 0 Only hotspots in the gene BRCA2 0.00 0 Only hotspots in the gene CDH1 0.00 0 Only hotspots in the gene CDKN2A 0.00 0 Only hotspots in the gene CSF1R 0.00 0 Only hotspots in the gene CTNNB1 0.00 0 Only hotspots in the gene DDR2 0.00 0 Only hotspots in the gene DNMT3A 0.00 0 Only hotspots in the gene EGFR 0.00 0 Only hotspots in the gene ERBB2 0.00 0 Only hotspots in the gene ERBB3 0.00 0 Only hotspots in the gene ERBB4 0.00 0 Only hotspots in the gene EZH2 0.00 0 Only hotspots in the gene FBXW7 0.00 0 Only hotspots in the gene FGFR1 0.00 0 Only hotspots in the gene FGFR2 0.00 0 Only hotspots in the gene FGFR3 0.00 0 Only hotspots in the gene FLT3 0.00 0 Only hotspots in the gene FOXL2 0.00 0 Only hotspots in the gene GNA11 0.00 0 Only hotspots in the gene GNAQ 0.00 0 Only hotspots in the gene GNAS 0.00 0 Only hotspots in the gene HNF1A 0.00 0 Only hotspots in the gene HRAS 0.00 0 Only hotspots in the gene IDH1 0.00 0 Only hotspots in the gene IDH2 0.00 0 Only hotspots in the gene JAK2 0.00 0 Only hotspots in the gene JAK3 0.00 0 Only hotspots in the gene KDR 0.00 0 Only hotspots in the gene KIT 0.00 0 Only hotspots in the gene KRAS 0.00 0 Only hotspots in the gene MAP2K1 0.00 0 Only hotspots in the gene MET 0.00 0 Only hotspots in the gene MLH1 0.00 0 Only hotspots in the gene MPL 0.00 0 Only hotspots in the gene MSH6 0.00 0 Only hotspots in the gene MTOR 0.00 0 Only hotspots in the gene NF1 0.00 0 Only hotspots in the gene NF2 0.00 0 Only hotspots in the gene NOTCH1 0.00 0 Only hotspots in the gene NPM1 0.00 0 Only hotspots in the gene NRAS 0.00 0 Only hotspots in the gene PDGFRA 0.00 0 Only hotspots in the gene PIK3CA 0.00 0 Only hotspots in the gene PIK3R1 0.00 0 Only hotspots in the gene PTCH1 0.00 0 Only hotspots in the gene PTEN 0.00 0 Only hotspots in the gene PTPN11 0.00 0 Only hotspots in the gene RB1 0.00 0 Only hotspots in the gene RET 0.00 0 Only hotspots in the gene SMAD4 0.00 0 Only hotspots in the gene SMARCB1 0.00 0 Only hotspots in the gene SMO 0.00 0 Only hotspots in the gene SRC 0.00 0 Only hotspots in the gene STK11 0.00 0 Only hotspots in the gene TERT 0.00 0 Only hotspots in the gene TP53 0.00 0 Only hotspots in the gene TSC1 0.00 0 Only hotspots in the gene VHL 0.00 0 Only hotspots in the gene -
Pancreas cancer (12 genes-) - ULB
Gene % of coding sequence sufficiently covered to detect heterozygous mutations Copy number variation Comments BRCA1 100.00 1 BRCA2 100.00 1 ATM 100.00 1 CDK4 100.00 1 CDKN2A 100.00 1 EPCAM 100.00 1 MLH1 100.00 1 MSH2 100.00 1 MSH6 100.00 1 PALB2 100.00 1 STK11 100.00 1 TP53 100.00 1 -
Pancreatic Cancer (9 genes) - KUL
Gene % of coding sequence sufficiently covered to detect heterozygous mutations Copy number variation Comments CDKN2A 100.00 1 MLH1 100.00 1 MSH2 100.00 1 MSH6 100.00 1 BRCA1 100.00 1 BRCA2 100.00 1 PALB2 100.00 1 TP53 100.00 1 STK11 100.00 1 -
Pediatric oncopredisposition - UGent
Gene % of coding sequence sufficiently covered to detect heterozygous mutations Copy number variation Comments A2ML1 99.97 1 ABCB11 99.86 1 ACD 100.00 1 AIP 99.99 1 ALK 99.93 1 APC 99.97 1 ASXL1 100.00 1 ATM 99.83 1 RNF2 99.99 1 BLM 99.80 1 BMPR1A 99.58 1 BRAF 99.78 1 BRCA1 98.33 1 BRCA2 99.99 1 BRIP1 99.39 1 BUB1B 100.00 1 CBL 99.95 1 CD27 99.95 1 CD70 99.99 1 CDC73 99.60 1 CDH1 99.98 1 CDK4 100.00 1 CDKN1B 100.00 1 CDKN1C 100.00 1 CDKN2A 100.00 1 CEBPA 100.00 1 CEP57 99.92 1 CREBBP 99.97 1 CTC1 100.00 1 CTLA4 99.99 1 CTR9 99.98 1 DDB2 100.00 1 DICER1 99.96 1 DIS3L2 99.90 1 DKC1 99.59 1 DNAJC21 99.67 1 EFL1 99.83 1 EGLN1 99.86 1 EGLN2 99.97 1 ELP1 99.96 1 EPAS1 99.99 1 EPCAM 99.89 1 ERCC2 99.98 1 ERCC3 99.90 1 ERCC4 99.92 1 ERCC5 99.99 1 ERCC6L2 99.94 1 ETV6 99.99 1 EZH2 99.89 1 FANCA 100.00 1 FANCB 99.24 1 FANCC 99.98 1 FANCD2 99.86 1 FANCE 99.99 1 FANCF 100.00 1 FANCG 100.00 1 FANCI 99.96 1 FANCL 99.67 1 FAS 99.99 1 FBXW7 99.90 1 FH 99.95 1 GATA1 99.97 1 GATA2 99.99 1 GPC3 99.60 1 GPC4 99.89 1 GPR161 99.92 1 HAVCR2 99.93 1 HRAS 100.00 1 IKZF1 99.92 1 ITK 99.91 1 KRAS 99.13 1 L2HGDH 99.92 1 LIG4 100.00 1 LZTR1 99.46 1 MAP2K1 99.98 1 MAP2K2 99.99 1 MAX 99.96 1 MDH2 99.54 1 MDM4 99.43 1 MEN1 99.98 1 MLH1 99.64 1 MRAS 99.97 1 MSH2 99.23 1 MSH6 99.97 1 MYSM1 94.16 1 NBN 99.93 1 NF1 99.88 1 NF2 100.00 1 NHP2 99.96 1 NOP10 99.99 1 NRAS 99.66 1 NSD1 99.98 1 PALB2 99.71 1 PARN 99.75 1 PAX5 99.82 1 PHOX2B 99.98 1 PIK3CA 99.74 1 PMS2 70.47 1 POLD1 99.96 1 POLE 99.99 1 POLH 99.85 1 POT1 99.91 1 PPP1CB 99.89 1 PRF1 100.00 1 PRKAR1A 100.00 1 PTCH1 99.99 1 PTEN 99.89 1 PTPN11 99.98 1 RAF1 99.97 1 RB1 99.84 1 RECQL4 100.00 1 REST 99.99 1 RET 99.97 1 RIT1 99.78 1 RMRP 100.00 1 RPL11 99.81 1 RPL15 31.77 1 RPL18 100.00 1 RPL26 30.55 1 RPL27 99.83 1 RPL35 99.99 1 RPL35A 97.55 1 RPL5 28.81 1 RPS10 0.00 1 RPS15A 22.14 1 RPS17 100.00 1 RPS19 100.00 1 RPS24 91.48 1 RPS26 8.99 1 RPS27 27.45 1 RPS28 100.00 1 RPS29 99.96 1 RPS7 88.50 1 RRAS 99.98 1 RRAS2 99.94 1 RTEL1 100.00 1 RUNX1 100.00 1 SAMD9 99.93 1 SAMD9L 99.95 1 SBDS 99.93 1 SDHA 99.98 1 SDHAF2 99.96 1 SDHB 97.32 1 SDHC 99.67 1 SDHD 82.93 1 SETBP1 100.00 1 SH2D1A 98.98 1 SHOC2 99.96 1 SLX4 100.00 1 SMARCA4 99.99 1 SMARCB1 99.99 1 SMARCE1 99.87 1 SOS1 99.68 1 SOS2 99.39 1 SRP72 99.91 1 STK11 100.00 1 SUFU 100.00 1 TERC 98.59 1 TERT 100.00 1 TINF2 100.00 1 TMEM127 99.99 1 TP53 99.98 1 TRIM28 100.00 1 TRIM37 98.19 1 TRIP13 100.00 1 TSC1 99.99 1 TSC2 99.98 1 TSR2 99.96 1 UBE2T 99.89 1 USB1 89.62 1 VHL 100.00 1 WAS 99.90 1 WRAP53 100.00 1 WT1 99.99 1 XPA 99.68 1 XPC 99.98 1 SRP54 99.90 1 -
Sturge-Weber syndrome (65 genes) - KUL
Gene % of coding sequence sufficiently covered to detect heterozygous mutations Copy number variation Comments ABL1 0.00 0 Only hotspots in the gene AKT1 0.00 0 Only hotspots in the gene ALK 0.00 0 Only hotspots in the gene APC 0.00 0 Only hotspots in the gene ATM 0.00 0 Only hotspots in the gene BRAF 0.00 0 Only hotspots in the gene BRCA1 0.00 0 Only hotspots in the gene BRCA2 0.00 0 Only hotspots in the gene CDH1 0.00 0 Only hotspots in the gene CDKN2A 0.00 0 Only hotspots in the gene CSF1R 0.00 0 Only hotspots in the gene CTNNB1 0.00 0 Only hotspots in the gene DDR2 0.00 0 Only hotspots in the gene DNMT3A 0.00 0 Only hotspots in the gene EGFR 0.00 0 Only hotspots in the gene ERBB2 0.00 0 Only hotspots in the gene ERBB3 0.00 0 Only hotspots in the gene ERBB4 0.00 0 Only hotspots in the gene EZH2 0.00 0 Only hotspots in the gene FBXW7 0.00 0 Only hotspots in the gene FGFR1 0.00 0 Only hotspots in the gene FGFR2 0.00 0 Only hotspots in the gene FGFR3 0.00 0 Only hotspots in the gene FLT3 0.00 0 Only hotspots in the gene FOXL2 0.00 0 Only hotspots in the gene GNA11 0.00 0 Only hotspots in the gene GNAQ 0.00 0 Only hotspots in the gene GNAS 0.00 0 Only hotspots in the gene HNF1A 0.00 0 Only hotspots in the gene HRAS 0.00 0 Only hotspots in the gene IDH1 0.00 0 Only hotspots in the gene IDH2 0.00 0 Only hotspots in the gene JAK2 0.00 0 Only hotspots in the gene JAK3 0.00 0 Only hotspots in the gene KDR 0.00 0 Only hotspots in the gene KIT 0.00 0 Only hotspots in the gene KRAS 0.00 0 Only hotspots in the gene MAP2K1 0.00 0 Only hotspots in the gene MET 0.00 0 Only hotspots in the gene MLH1 0.00 0 Only hotspots in the gene MPL 0.00 0 Only hotspots in the gene MSH6 0.00 0 Only hotspots in the gene MTOR 0.00 0 Only hotspots in the gene NF1 0.00 0 Only hotspots in the gene NF2 0.00 0 Only hotspots in the gene NOTCH1 0.00 0 Only hotspots in the gene NPM1 0.00 0 Only hotspots in the gene NRAS 0.00 0 Only hotspots in the gene PDGFRA 0.00 0 Only hotspots in the gene PIK3CA 0.00 0 Only hotspots in the gene PIK3R1 0.00 0 Only hotspots in the gene PTCH1 0.00 0 Only hotspots in the gene PTEN 0.00 0 Only hotspots in the gene PTPN11 0.00 0 Only hotspots in the gene RB1 0.00 0 Only hotspots in the gene RET 0.00 0 Only hotspots in the gene SMAD4 0.00 0 Only hotspots in the gene SMARCB1 0.00 0 Only hotspots in the gene SMO 0.00 0 Only hotspots in the gene SRC 0.00 0 Only hotspots in the gene STK11 0.00 0 Only hotspots in the gene TERT 0.00 0 Only hotspots in the gene TP53 0.00 0 Only hotspots in the gene TSC1 0.00 0 Only hotspots in the gene VHL 0.00 0 Only hotspots in the gene